Effect of growth factors on Escherichia coli alpha-hemolysin-induced mediator release from human inflammatory cells: Group 2 - Cycle 1 and 3: Update Part 2. No Criteria Inclusion Criteria:. Request Permissions View permissions information for this article.
Loratadine and Bone Pain
Evaluation of Loratadine for Prevention of Pegfilgrastim-Induced Pain The recruitment status of this study is unknown. The mechanisms of bone pain secondary to G-CSFs are not fully known, but research has shown that histamine release is involved in the inflammatory process. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: Volume 17, Issue 9.
Across all cycles the maximum is the maximum of each patient-reported bone pain value across all survey days and across all cycles.
Warning You have reached the maximum number of saved studies March Final data collection date for primary outcome measure. They may also be used for mobilization of stem cells prior to autologous hematopoietic stem cell transplant, and in other indications to prevent adverse outcomes due to neutropenia. Bone pain is the most notorious adverse effect caused by G-CSFs.
Purpose The purpose of this study is to determine the incidence of pegfilgrastim-induced back and leg pain and to determine whether the antihistamine loratadine can prevent pegfilgrastim-induced back and leg pain. Allergy Asthma Proc ; Listing a study does not mean it has been evaluated by the U.
Breakthroughs on the Horizon. Please refer to this study by its ClinicalTrials. Schwartz noted that granulocyte colony-stimulating factor G-CSF —induced bone marrow expansion of white blood cell precursors has been associated with histamine release and possibly pain.
Severe pegfilgrastim-induced bone pain completely alleviated with loratadine: Purpose The goal of this clinical research study is to learn if loratadine can control bone pain caused by pegfilgrastim a drug given after chemotherapy to help raise white blood cell counts. There is limited reported use of antihistamines to treat G-CSF—induced bone pain; however, 2 drugs have shown promise in published literature. Loratadine use continued throughout the remainder of her treatment, which included a change in chemotherapy due to disease progression, without incidence of bone pain.
Karen M Wilson, MEd karen. Finally, she was prescribed loratadine 10 mgwhich she was instructed to take the day before, the day of, and for 5 days after chemotherapy. The precise underlying mechanism behind the bone pain is unknown; it may be caused by expansion of bone marrow resulting from increases in hematopoietic progenitor cells and histamines as part of an immunologic response brought on by G-CSF.