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Global strategy for the diagnosis, management and prevention of COPD. This article aims to critically review the international literature relating to the long-term effectiveness and safety of macrolides and to estimate the budget impact of preventing exacerbations with azithromycin in Belgium.

Cigarette smoking is implicated in 90 percent of cases and, along with coronary artery disease, is a leading cause of disability.


This indicated that a relative shorter-term therapy might not bring significant benefits. Two studies included patients requiring aerosolized antibiotics or systemic steroids [ 1921 ] and 1 study recruited patients who had been treated with theophylline and inhaled anticholinergic agents but not inhaled corticosteroids [ 13 ].

Azithromycin for prevention of exacerbations of COPD. Despite the constant emergence of resistance to antibiotics by H. Murphy TF, Sethi S. Data Extraction and Quality Assessment The following variables were collected from the included studies by 2 independent reviewers: Gastrointestinal reactions were the most frequent adverse events in the treatment groups.

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We systematically searched PubMed, Embase and the Cochrane Library from their inception until September 30th using the following search term: Eur J Pharmacol ; Theophylline may induce short-term improvement of the FEV 1but the benefits of methylxanthine therapy should be weighed against potential side effects and possible toxicity. Culture was performed according to standard microbiological methods Subgroup analysis showed only 6—12 months of erythromycin or azithromycin therapy could be effective.

European Respiratory Journal The response clinical and bacteriological data were analysed by centre-adjusted Cochran—Mantel—Haenszeltests. Safety and adverse events Forty-nine patients, 24 9. Infectious etiology of acute exacerbations of chronic bronchitis.

Baseline characteristics of the modified intention-to-treat m-ITT population. The remaining 25 to 30 percent of cases are usually caused by viruses. Methods Study design and patients The current prospective randomised multicentric double-blind comparative study was performed using a double-dummy design with two-arm parallel groups.


Therapy with azithromycin improved cough-specific health status and thus significantly reduced the SGRQ total score [ 19 ].

Epidemiology of community-acquired respiratory tract infections in adults.

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