Propanolol is extensively metabolized with most metabolites appearing in the urine. Jean C, Laplanche R. The beta-blockers so far studied are rapidly distributed in the body. Eur J Drug Metab Pharmacokinet. National Institute for Health and Clinical Excellence.
The glucuronidation of the parent drug is also one of the major metabolic pathways [ 61 ]. Journal of Pharmacy and Pharmacology. There are two metabolic pathways for spironolactone degradation. A model for predicting likely sites of CYP3A4-mediated metabolism on drug-like molecules.
D Evidence of risk. Detailed description of antihypertensive drugs metabolism according to the 3 rd level E. For instance, the antihypertensive drugs which are known not to undergo metabolism amiloride, atenolol, hydrochlorotiazide, nadolol, chlorthalidone, chlorothiazide have been classified among the two classes described as the poor metabolizing drugs.
Nimodipine follows hepatic metabolism mediated by CYP3A4. Pindolol disposition and metabolism in rhesus monkeys after chronic treatment. DrugBank a knowledgebase for drugs, drug actions and drug targets. Calcium channel blockers bepridil, diltiazem, felodipine, flunarizine, isradipine, nicardipine, nifedipine, nimodipine, verapamil or Clonidine or Guanabenz: In patients with impaired liver function an increase of the volume of distrubution of propranolol has been found.
It has been used to predict some of the major metabolic pathways and to identify the role of P enzymes [ 1920 ]. In current cardiovascular disease pharmacology, four drug clusters - Angiotensin Converting Enzyme Inhibitors, Beta-Blockers, Calcium Channel Blockers and Diuretics - cover the major therapeutic characteristics of the most antihypertensive drugs.
Renal Lactic In lactiferous females. For injection dosage form: Following similar metabolic profile, nadolol is a poorly lipid-soluble drug and is excreted unchanged in the urine [ 60 ]. Combination of docking, molecular dynamics and quantum mechanical calculations for metabolism prediction of 3, 4-methylenedioxybenzoylthienylhydrazone.
It has been comprehensively described that extensive variability of anti-hypertensive drugs plasma concentrations in patients, due to the Pmediated drugs metabolism, has a great impact and influence on the clinical outcome as well as on the drugs' response [ 1 ]. Biotransformation of felodipine in liver microsomes from rat, dog, and man. InHatzimanikatis et al. The model of PPS Pathway Prediction System also uses metabolic rules describing the transformation of chemical functional groups [ 2930 ].