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It may also delay progression of diabetic nephropathy and is associated with a positive clinical outcome in that regard. From Wikipedia, the free encyclopedia. Losartan is generally marketed as the basic potassium salt of the aromatized negatively charged tetrazolecalled "losartan potassium. In addition, the binding to the target enzyme is pH-sensitive, and the negatively-charged tetrazole ring, which is similar in size to the negative carboxylic acid derivative, may contribute to the activity of the drug.

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In other projects Wikimedia Commons. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most patients due to both efficacy [ citation needed ] and costan angiotensin II receptor antagonist such as losartan is recommended as first-line treatment in patients under the age of 55 who cannot tolerate an ACE inhibitor.

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The terminal elimination half lives of losartan and EXP are about 1. Reduction in blood pressure occurs independently of the status of the renin-angiotensin system. As a specific inhibitor of the urate transporter 1 SLC22A12URAT1losartan blocks the uptake of uric acid into cells, thus leaving more available in the bloodstream to be filtered and excreted by the kidneys.

More serious side effects include low blood pressure and allergic reaction. The most common side effects for losartan are upper respiratory infections or stuffy nose, dizziness, and back pain.

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The maximal effects on blood pressure usually occur within 3—6 weeks of starting losartan. Views Read Edit View history.

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All of the physiological effects of angiotensin II, including release of aldosteroneare antagonized in the presence of losartan. As with all angiotensin II type 1 receptor AT 1 antagonists, losartan is indicated for the treatment of hypertension.

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This page was last edited on 1 Novemberat Losartan should not be taken by people who are diabetic and taking aliskiren. Captopril Rentiapril Zofenopril Dicarboxylate-containing: Retrieved from " https: Losartansold under the trade name Cozaar among others, is an angiotensin II receptor antagonist drug used mainly to treat high blood pressure hypertension. Gemopatrilat Ilepatril Omapatrilat Sampatrilat.

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Losartan is well absorbed following oral administration and undergoes significant first-pass metabolism to produce the 5- carboxylic acid metabolite, designated as EXP Losartan administration results in a decrease in total peripheral resistance afterload and cardiac venous return preload. It is on the World Health Organization's List of Essential Medicinesthe most effective and safe medicines needed in a health system.

Uses authors parameter CS1 maint: By using this site, you agree to the Terms of Use and Privacy Policy. American Journal of Hypertension: In Januarythe FDA issued a black box warning that losartan can cause fetal toxicity, and should be discontinued as soon as pregnancy is detected.

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