Further work is needed to determine the effect of CCBs on cyclosporine pharmacokinetics, especially with respect to their metabolism by gut and hepatic cytochrome P enzymes, and their effect on patient outcome. Journal List Ann Surg v.
Understand Immunotherapy Painful Knees? Norvasc amlodipine US Prescribing Information. Mitochondrial calcium accumulation and respiration in ischemic acute renal failure in the rat. Verapamil inhibits cyclosporin metabolism. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
Cyclosporine/Calcium Channel Blockers
To determine the effect of calcium-channel blockers CCBs on cyclosporine dose, clearance, and cost, and their effect on kidney graft function and survival in patients who underwent kidney transplant. Br J Exp Pathol. Not a Medscape Member? Please refer to this blog post for more information. Disease and Condition Articles. Influence of nicardipine on renal function and plasma cyclosporin in renal transplant patients.
National Center for Biotechnology InformationU. Check for more interactions with the Drug Interaction Checker. Calcium channel blockers have immunomodulating effects in vitro and may be effective in preventing cyclosporine nephrotoxicity.
Significant Potential for significant interaction monitoring by your doctor is likely required. Joint Accredited with multiple accreditations, including:. Lancet Jun 14;1 Please check with a physician if you have health questions or concerns. Effects on the cis-diamminedichloroplatinum-treated isolated perfused kidneys. Supplemental Content Full text links. Lack of effect of the calcium antagonist isradipine on cyclosporine pharmacokinetics in renal transplant patients.
Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity. Role of calcium in pathogenesis of acute renal failure. National Center for Biotechnology InformationU.
Lancet May 30;1 BMJ Nov 11; A wonderful resource tool with great updates.