Modulation of Tamoxifen Cytotoxicity by Caffeic Acid Phenethyl Ester in MCF-7 Breast Cancer Cells
In the present investigation, both Bcl-2 and Beclin 1 expression levels were downregulated in all treated groups. Asian Pac J Cancer Prev. Alvetex Scaffold Application Note Certain aspects of cancer research rely on animal models but these have associated feasibility and ethical concerns [1,2]. Contact us Editorial email: Breast cancer is the most prevalent cancer among the female population [ 1 ].
This step was followed by incubation with the appropriate diluted secondary antibody 1: To receive news and publication updates for Oxidative Medicine and Cellular Longevity, enter your email address in the box below.
It contains antioxidant molecules such as flavonoids, phenolic acids, catalase, carotenoids, peroxidase and catalase [ 11 ]. In this context, Qadir et al.
However the sensitivity patterns obtained on Alvetex Scaffold well plate technology are different to standard 2D assay responses, showing this three-dimensional technology could provide a more sensitive and accurate tool for the use of in vitro sensitivity assays in cancer research and drug development.
Akim 1 Email author E. There was also no evidence of toxicity by void polymeric nanoparticles. Tamoxifen, a commonly used drug in hormone receptor-positive breast cancer, is an antagonist of the estrogen receptor in breast tissue by the common metabolite hydroxytamoxifen.
However, tamoxifen produces adverse effects that could be due to its ability to induce cellular DNA damage. They also acknowledge the National Cancer Institute, Cairo, Egypt, for its great support throughout the experimental work. SW cells after 72 hours culture period and exposure to doxorubicin for 72 hours.
Jungle honey enhances immune function and antitumor activity. Google Scholar Bush NJ: The discrepancy between our result and other researchers may be due to time of detection of autophagosomes and interplay between autophagy and other players as oxidative stress, metabolites, and apoptosis. Ocular toxicity of systemic anticancer chemotherapy. Authors Authors and affiliations A. IC50 values A 2. Nitric oxide produced in cell culture media was estimated spectrophotometrically [ 23 ].
The Malaysian Tualang honey TH is not only cytotoxic to human breast cancer cell lines but it has recently been reported to promote the anticancer activity induced by tamoxifen in MCF-7 and MDA-MB cells suggesting its potential as an adjuvant for the chemotherapeutic agent. To our knowledge, no autophagy marker is currently available in order to discriminate between an increase or a decrease of overall autophagy flux in vivo [ 38 ]. The competency to increase response and reduce chemoresistance of cancer therapeutics via the use of the combination therapy might thus be a significant advantage for cancer patients.