Agranulocytosis has also been reported. Studies have shown Zyprexa creates an increased insulin resistance which inhibits extraction of glucose from the blood and ultimately leads to hyperglycemia.
For specific information about the adverse reactions observed with lithium or valproate, refer to the Adverse Reactions section of the package inserts for these other products. According to the package insert, the most common side effects of Zyprexa are dizziness, constipation, abnormal behavior, dry mouth, weight gain, low blood pressure upon standing, and weakness.
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Mean increase in weight in adolescents was greater than in adults.
There are no adequate and well-controlled trials with olanzapine in pregnant females. Weight effects associated with antipsychotics: The majority of these elevations were mild, and remained below 2 x ULN. Last reviewed on RxList: Dosage adjustments, if indicated, can be made according to efficacy and tolerability within dose ranges of oral olanzapine 5 to Thrombocytopenia Extended-release IM injection: Sedation up to The information below for olanzapine is derived from a clinical trial database for olanzapine consisting of 10, adult patients with approximately patient-years of exposure to olanzapine plus patients with exposure to intramuscular olanzapine for injection.
Dose Dependency of Adverse Reactions A dose group difference has been observed for fatigue, dizziness, weight gain and prolactin elevation. Events occurred in less than 0. Some instances of ALT elevations occurring on olanzapine therapy may be due to nonalcoholic fatty liver disease caused by weight gain that occurs in at least one-quarter of treated patients generally during the first 1 to 2 years of therapy.
Pulmonary embolism Extended-release IM injection: Photosensitivity reaction Postmarketing reports: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Akinesia, choreoathetosis, cogwheel rigidity, dyskinesia, dystonia, extrapyramidal disorder, generalized spasm, hypersomnia, hypokinesia, masked facies, movement disorder, myoclonus, opisthotonos, tardive dyskinesia, twitching Postmarketing reports: Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:.
List Zyprexa side effects by likelihood and severity.
Digestive System — Infrequent: Amount Gained kg lb. Eosinophilia, leukopenia, neutropenia Rare 0. Review of hepatotoxicity of psychiatric agents mentions that olanzapine has rarely been implicated in causing clinically apparent hepatic toxicity.
I have been of Zyprexa cold turkey after puting on 30 pounds, so it has been five days I am still suffering from nausea and headaches and loss of appetite.
Olanzapine Monotherapy in Adults — In an analysis of 5 placebo-controlled olanzapine monotherapy studies with treatment duration up to 12 weeks, olanzapine-treated patients had increases from baseline in mean fasting total cholesterol, LDL cholesterol, and triglycerides of 5.
Tell your health care provider about any negative side effects from prescription drugs.