However, CYP3A4 inhibitors such as macrolides increase the plasma concentrations of lovastatin and simvastatin by up to fold while only increasing the concentration of atorvastatin by up to 4-fold.
This results in lower bioavailability and simvastatin is therefore more susceptible to medicine interactions 1. Increased risk of myopathy when used with fibrates; do not exceed 10 mg simvastatin daily except with fenofibrate ; gemfibrozil increases systemic exposure to simvastatin.
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Erythromycin coadministration increases plasma atorvastatin concentrations. Features and specialized departments cover medication errors, drug interactions, patient education, pharmacy technology, disease state management, patient counseling, product news, pharmacy law and health-system pharmacy.
The information provided here is for informational purposes only. Azithromycin is usually prescribed for a shorter time than the other antibiotics studied and it's possible that other factors such as duration of treatment were behind the differences observed. Sign up for the PharmacyTimes Newsletter. Simvastatin and atorvastatin, two widely prescribed cholesterol lowering medicines, are both metabolised by the isoenzyme cytochrome P 3A4 CYP3A4.
Atorvastatin; Pitavastatin (<=1mg); Pravastatin/Erythromycin
Find out more about cookies. Serious - Use Alternative Possible serious or life-threatening interaction. Furthermore, gemfibrozil increases systemic exposure to simvastatin, atorvastatin, and rosuvastatin Crestor. Lipitor atorvastatin US prescribing information. Women's Health Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.
This information is generalized and not intended as specific medical advice. Nunavut youth use music to keep suicide at bay Superbug 'The enemy of my enemy is my friend: A study of the interaction potential of azithromycin and clarithromycin with atorvastatin in healthy volunteers.
Do not start, stop, or change the dosage of any medicine before checking with them first. For rosuvastatin, start with 5 mg and do not exceed 20 mg during use with fibrates.
While the magnitude of potential interactions and the potential risk of muscle toxicity supported the recommendations, no specific risk data were available. They also suggested that clinicians be aware of the most commonly observed drug interactions with statins, noting that free online drug interaction programs exist.
Check for more interactions with the Drug Interaction Checker. Patients who are receiving warfarin should have INR monitoring before starting statins and regularly throughout treatment, especially with statin dose changes.
Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Your doctor may want to adjust the dose of your cholesterol medicine while you are taking your antibiotic. Those subjects were compared with statin users in the province prescribed another antibiotic, azithromycin, that does not block the liver enzyme the same way.