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Overview Side Effects Dosage More. Add small portions of chosen vehicle and mix to a uniform paste; mix while incrementally adding the vehicle to almost mL; transfer to a calibrated bottle, rinse mortar with vehicle, and add sufficient quantity of vehicle to make mL.

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Severe or life-threatening myelosuppression may occur at the recommended dose. Lipegfilgrastim should be administered at least 24 hours after the completion of myelosuppressive cytotoxic chemotherapy. Coccidioides immitis Skin Test: Women of reproductive potential should be advised to avoid becoming pregnant during treatment verify pregnancy status prior to starting hydroxyurea therapy and should use effective contraception during and for at least 6 months after completion of therapy.

Data from an open-label, randomized trial in patients with essential thrombocythemia at high risk for vascular events supports the use of hydroxyurea in combination with low-dose aspirin for the management of this condition [Harrison ]. If eye s contact with crushed or opened capsules occurs, the affected area should be flushed thoroughly with water or isotonic eyewash designated for that purpose for at least 15 minutes.

A clinical response to treatment may take 3 to 6 months; a 6 month trial on the maximum tolerated dose is recommended prior to considering discontinuation due to treatment failure; effectiveness of hydroxyurea depends upon daily dosing adherence. Hyperuricemia may occur with antineoplastic treatment; adequate hydration and initiation or dosage adjustment of uricosuric agents eg, allopurinol may be necessary.

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Immunization with live vaccines may result in severe infection. Stir vigorously using a magnetic stirrer for several hours, then filter to remove insoluble contents. Immunosuppressants may diminish the therapeutic effect of Vaccines Inactivated. Distributes widely into tissues including into the brain ; estimated volume of distribution approximates total body water Gwilt ; concentrates in leukocytes and erythrocytes.

Interrupt treatment; following recovery, may resume with a dose reduction of 2.

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Avoid the use of lenograstim 24 hours before until 24 hours after the completion of myelosuppressive cytotoxic chemotherapy. Data from a nonrandomized, retrospective study evaluating multiple therapies in patients with hypereosinophilic syndrome supports the use of hydroxyurea in the treatment of patients with this condition [Parillo ]. Head and neck cancer Hydrea: Essential thrombocythemia, high-risk off-label use: Management of sickle cell anemia to reduce the frequency of painful crises and to reduce the need for blood transfusions in patients with recurrent moderate to severe painful crises.

May cause macrocytosis, which can mask folic acid deficiency; prophylactic folic acid supplementation is recommended. Avoid concomitant use of lipegfilgrastim and myelosuppressive cytotoxic chemotherapy. Do not initiate therapy if bone marrow function is markedly reduced. May enhance the immunosuppressive effect of Immunosuppressants.

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If the powder from the capsule is spilled, immediately wipe it up with a damp disposable towel and discard along with the empty capsules in a closed container, such as a plastic bag.