The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient.
Stop using antibiotics in healthy farm animals, WHO warns read comments Drug costs rising fast in Canadian health-care spending, report finds read comments Health Canada eases restrictions on abortion pill Mifegymiso Bad news: Find out about statins, a group of medicines used to lower LDL cholesterol levels in the blood.
Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The CYP3A4-inhibiting qualities of clarithromycin cannot explain the increased risk of statin toxicity observed in the study, as only statins that were not metabolized by this enzyme were assessed, the authors write.
A study of the interaction potential of azithromycin and clarithromycin with atorvastatin in healthy volunteers.
Abstract Background Clarithromycin, known as a potent inhibitor of the cytochrome P isoenzyme CYP3A, may increase the plasma concentration of statins metabolized by this pathway; therefore, increase the risk of interaction with statins in reference to pharmacokinetic studies. Statins are frequently prescribed with antibiotics.
Ciclosporin is contraindicated with rosuvastatin Crestor. Am J Cardiol Nov 1;94 9: Men's Health Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.
In addition, the possibility of a transient interruption of statin intake during clarithromycin therapy by physician advice was not accessible from our database.
It can be treated with lifestyle changes. In total, 69, HMG CoA reductase inhibitors were prescribed in clarithromycin users independent of co-administration during the observation period Fig.
More in High Cholesterol
The sensitivity analyses did not change the significance of effect. Contraindicated unless benefits outweigh risks and no alternatives available. Rosuvastatin Rosuvastatin is not associated with cytochrome P interactions. Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: Check for more interactions with the Drug Interaction Checker. Please use one of the following formats to cite this article in your essay, paper or report: This page was printed from: Subscriptions Go to the Subscriptions Centre to manage your: However, limited evidence from controlled studies confirms and measures the potential risk of serious adverse events due to this interaction [ 92425 ].
Get the most out of Medical News Today. Healthcare professionals should refer to Summaries of Product Characteristics for full details of interactions.
To view content sources and attributions, please refer to our editorial policy.